What's going on in Parkinson's disease?
December 25th 2009 06:16
In PD the patient's brain has neurotransmitter imbalance. Neurotransmitter are substances which signal specific instructions for proper functioning of our nervous system.
In this case the neurotransmitter imbalance is between dopamine and acetylcholine. dopamine becomes less, and because of this nothing restricts the excitatory functions of acetylcholine. And so the muscles are always contracted (excited), even in an individual's resting state.
Dopamine usually is secreted in the substantia nigra of the brain. And so if this part of the brain is affected, there is nothing to produce dopamine-result rigidness of the arms, trunk, and legs.
They say that gene defects can contribute to such degeneration, and a time comes when an affected individual would express such defect on the substantia nigra. Trauma to the head may also be contributory, as boxers would manifest the disease later on in their lives.
it is important that a person affected by the condition seeks medical attention, especially of a neurologist. L-dopa is an important element in managing movement disorders, but mind you, such management is only supportive. Because the length that a patient would go symptomless would depend on the potency of the drugs given to them.
Physical therapy is also important. Exercises will be given to affected persons, depending on their needs and present capabilities. Gait training is also beneficial for patients. And more importantly, PT is being employed to slow-down or even prevent the development of complications (which include muscle atrophy, muscle tightness and contractures, lung problems, bed sores, etc.).
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MY PERSONAL INSIGHTS 'BOUT THE 2009 NBA FINALS- HERE
In this case the neurotransmitter imbalance is between dopamine and acetylcholine. dopamine becomes less, and because of this nothing restricts the excitatory functions of acetylcholine. And so the muscles are always contracted (excited), even in an individual's resting state.
Dopamine usually is secreted in the substantia nigra of the brain. And so if this part of the brain is affected, there is nothing to produce dopamine-result rigidness of the arms, trunk, and legs.
They say that gene defects can contribute to such degeneration, and a time comes when an affected individual would express such defect on the substantia nigra. Trauma to the head may also be contributory, as boxers would manifest the disease later on in their lives.
it is important that a person affected by the condition seeks medical attention, especially of a neurologist. L-dopa is an important element in managing movement disorders, but mind you, such management is only supportive. Because the length that a patient would go symptomless would depend on the potency of the drugs given to them.
Physical therapy is also important. Exercises will be given to affected persons, depending on their needs and present capabilities. Gait training is also beneficial for patients. And more importantly, PT is being employed to slow-down or even prevent the development of complications (which include muscle atrophy, muscle tightness and contractures, lung problems, bed sores, etc.).
----------------------
MY PERSONAL INSIGHTS 'BOUT THE 2009 NBA FINALS- HERE
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